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SUMOylation of HSPA9 impairs therapeutic efficacy by promoting damaged mitochondria transfer in intervertebral disc degeneration

Name: SUMOylation of HSPA9 impairs therapeutic efficacy by promoting damaged mitochondria transfer in intervertebral disc degeneration
Creator: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Published: 2026-01-10T11:10:36+08:00

integrated proteome resources2026-02-07 收录

椎间盘退变机制

蛋白质SUMO化修饰

数据链接：

https://www.iprox.cn/page/project.html?id=IPX0015107000 数据链接链接失效反馈

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资源简介：

SUMOylation of HSPA9 impairs therapeutic efficacy by promoting damaged mitochondria transfer in intervertebral disc degeneration

应用场景：

提供机构：

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

创建时间：

2026-01-10

椎间盘退变机制

细胞生物力学

Nucleus pulposus cells were stretched using a FX-5000T Flexcell tension plus system (Flexcell International Corp., USA) with 18% elongation (0.2 Hz) for 24 h Overall design: To compare the effects of

NIAID Data Ecosystem90

GLUT1 is redundant in hypoxic and glycolytic nucleus pulposus cells of the intervertebral disc. GLUT1 is redundant in hypoxic and glycolytic nucleus pulposus cells of the intervertebral disc

骨髓代谢

椎间盘退变机制

Glucose is critical to the development, homeostasis, and survival of nucleus pulposus cells. GLUT1 is a major glucose transporter, a NP phenotypic cell marker, and highly expressed in nucleus pulposus

NIAID Data Ecosystem40

Propionibacterium acnes induces intervertebral disc degeneration by promoting nucleus pulposus cell apoptosis via the TLR2/JNK/mitochondrial-mediated pathway

椎间盘退变机制

细胞凋亡通路

Evidence suggests that intervertebral disc degeneration (IVDD) can be induced by Propionibacterium acnes (P. acnes), although the underlying mechanisms are unclear. In this study, we analyzed the path

Figshare2019-04-02 更新20

Bushenhuoxue formula on Wnt/β-catenin signaling

椎间盘退变机制

中医干预

椎间盘退行性变（IDD）是腰痛的主要原因。本研究旨在探讨IL-1对IDD的影响及其与Wnt/β-连环蛋白信号传导的关系，并初步阐明中国传统配方布氏菌素配方（BSHXF）的影响。将30只C57BL/6小鼠随机分为正常对照组、椎间盘变性模型组、β-连环蛋白基因激活组、BSHXF+β-连环蛋白基因激活组和BSHXF+椎间盘变性模型组。8周后，进行影像学和组织病理学分析。观察椎间盘的病理变化，检测相关蛋白

Figshare2022-06-28 更新60

Reactive Oxygen Species promote Pyroptosis of Nucleus Pulposus Cells in Modic changes with disc herniation based on smart-RNA sequencing

椎间盘退变机制

焦亡与氧化应激

We performed Smart-seq 2 and analyzed the differential expression of genes and pathways of Modic change to comparator group. Additionally, we detect the role of reactive oxygen species on pyroptosis o

NIAID Data Ecosystem40

SUMOylation of HSPA9 impairs therapeutic efficacy by promoting damaged mitochondria transfer in intervertebral disc degeneration

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