Additional file 2 of Univariable and multivariable Mendelian randomization study identified the key role of gut microbiota in immunotherapeutic toxicity

Additional file 2: Table S1. All Instrumental variables used for gut microbiota in the MR analysis. Table S2. Full results of primary MR analysis between bacterial taxa and all-grade irAEs. Table S3. Full results of primary MR analysis between bacterial taxa and high-grade irAEs. Table S4. Results of ΜR PRESS Global test. Table S5. Instrumental variables for irAEs in the reverse MR analysis. Table S6. Results of reverse MR analysis between all-grade irAEs and the identified significant gut bacterial taxa. Table S7. Results of reverse MR analysis between high-grade irAEs and the identified significant gut bacterial taxa. Table S8. Results of heterogeneity and horizontal pleiotropy analysis in reverse MR analysis. Table S9. PhenoScanner results of instrumental variables used for significant bacterial taxa in the MR analysis. Table S10. Description of data sets used for weight-associated anthropometric and lifestyle factors in univariable MR analysis. Table S11. Multivariate MR estimates between gut microbiota (adjusted for BMI) and irAEs.