Cardiac fibroblasts behave differently to isoproterenol-induced injury based on their genetic variability

The goal of this study is to characterize molecular mechanisms that regulate cardiac fibrosis This study compare the fibrotic response of ISO-treated hearts in 3 strains of mice (B6, C3H and KK) Overall design: Expression profiles of Thy1+ HE cells from saline and ISO-treated hearts (day 14 and 21) were generated using sequencing on the Illumina Hi-seq 3000 platform