Differential gene expression analysis of MYCN-amplified neuroblastoma cells after transfection with Control siRNA, LYAR siRNA-6 or LYAR siRNA-10. Homo sapiens

N-Myc oncoprotein induces neuroblastoma and exerts its biological effects through modulation of its target genes. We identified that MYCN modulates LYAR expression and we are interested to determine which signaling pathway LYAR regulates. Overall design: We performed Affymetrix microarray experiments in BE(2)-C cells after transfection with control siRNA, LYAR siRNA-6 or LYAR siRNA-10 for 32 hours.