Comprehensive cell atlas of human embryos with chromosome aneuploidy

Aneuploidy has profound effects on eukaryotic cells. In humans, aneuploidy is associated with various pathologies, including cancer, which suggests that it mediates a proliferative advantage under these conditions. However, there are still many questions about the mechanism of embryo dysplasia in chromosome aneuploidy: How dose differences on specific chromosomes affect gene expression on other chromosomes? What is the main difference between the aneuploidy abnormality of the fatal chromosome and the aneuploidy abnormality of the non-fatal chromosome. Here, by combining an in vitro culture system for the blastocyst and single cell transcriptome sequencing technologies, we examine more than 13000 individual cells from each type of aneuploidy during blastula stage.