Supplementary Material for: Interactions between Traumatic Brain Injury and Frontotemporal Degeneration

<b><i>Background/Aims:</i></b> Prior work in smaller cohorts suggests that traumatic brain injury (TBI) may be a risk factor for frontotemporal degeneration (FTD). We sought to confirm and extend these results using the National Alzheimer's Coordinating Center Uniform Data Set. <b><i>Methods:</i></b> We compared the TBI prevalence between FTD subjects and matched normal controls. Indices of cognitive, behavioral, functional, and global dementia severity were compared between FTD subjects with and without prior TBI. <b><i>Results:</i></b> Remote TBI with extended loss of consciousness (TBI-ext) was more common in individuals with FTD than in controls (OR: 1.67; 95% CI: 1.004-2.778). With TBI-ext, less functional and global impairment was seen in the behavioral variant of FTD, but more behavioral pathology was seen in the semantic variant. <b><i>Conclusion:</i></b> TBI may increase the FTD risk and influence clinical symptomatology and severity in FTD subtypes.