Estimates of chromosome and sex-specific ratios of gene expression, ATAC-seq peak height and 5mC methylation levels in liver and spleen tissue.

Values are shown for the regulatory region of a gene (peak height: transcription start/end sites, 5mC methylation: CpG islands); for values integrating across the entire gene consult S2 Table. The color code categorizes 95% confidence intervals (shown in brackets) into biologically meaningful categories consistent with ratios of 1 (blue),] 0.5;1] (yellow) or larger than 1 (green). Autosomal ratios AAf:AAm and ZZm:AAm constitute the null expectation and should not differ from unity for any of the three measures (blue). For gene expression, values within] 0.5;1] (yellow) indicate partial dosage balance and compensation. For peak height values above 1 (green) indicate a more permissive chromatin environment on the female Z chromosome with the potential to induce partial dosage balance and compensation. For 5mC methylation, values < 1 (yellow) indicate tissue-specific hypomethylation on the Z chromosome in both sexes. A: autosomes, Z: Z chromosome, f: female, m: male.