Enantioselective Synthesis of Multisubstituted Biaryl Skeleton by Chiral Phosphoric Acid Catalyzed Desymmetrization/Kinetic Resolution Sequence
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https://figshare.com/articles/dataset/Enantioselective_Synthesis_of_Multisubstituted_Biaryl_Skeleton_by_Chiral_Phosphoric_Acid_Catalyzed_Desymmetrization_Kinetic_Resolution_Sequence/2434960
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资源简介：
Described
herein is the enantioselective synthesis of multisubstituted
biaryl derivatives by chiral phosphoric acid catalyzed asymmetric
bromination. Two asymmetric reactions (desymmetrization and kinetic
resolution) proceeded successively to afford chiral biaryls in excellent
enantioselectivities (up to 99% ee). Both experimental and computational
studies suggested that this excellent selectivity could be achieved
via a highly organized hydrogen bond network among a substrate, a
catalyst (chiral phosphoric acid), and a brominating reagent (N-bromophthalimide).
创建时间：
2016-02-19
