Paternal age and Offspring DNA methylation (for manuscript: Yeung et al. Maternal age is related to offspring DNA methylation: A meta-analysis of results from the PACE consortium. Aging Cell 2024; PMID: 38808605)

Data sharing files (DSF) 8, 9, 10. Meta-analysis of single CpG associations from the set of Illumina 450K microarray probes between paternal age at birth (in years) with newborn blood DNA methylation. Meta-analyses of results from robust linear regression models adjusting for 3 separate sets of covariates: 8) minimal adjustment for cell type estimation, batch, and selection (as applicable from each cohort), 9) main adjustment for cell type estimation, paternal smoking, paternal education, paternal race/ethnicity/ancestry, maternal parity, batch, and selection (as applicable from each cohort), and 10) BMI adjustment for above + paternal BMI. In DSF11, meta-analysis was conducted in cohorts providing data from childhood blood samples. In DSF12. Meta-analysis of single CpG associations from the set of Illumina EPIC microarray probes between paternal age at birth modeled as a continuous variable (in years) with newborn blood DNA methylation. In DSF13 and 14: Additional sensitivity meta-analysis was conducted with adjustment for main covariates + offspring sex in newborn and childhood blood samples, respectively.DSF8-10 and 13: Direction of associations correspond to the cohorts providing data in the following order: ALSPAC, NORTHPOP, GenR, POSEIDON, EARLI, MARBLES, CHAMACOS, INMA, MoBa1, MoBa2, MoBa4, MoBa8, UKIDS, CHS. NORTHPOP was dropped from BMI models. DSF12: Direction of associations correspond to the cohorts providing EPIC microarray data in the following order: NORTHPOP, MARBLES, MoBa4, MoBa8, UKIDS. DSF11 and 14: Direction of associations correspond to the cohorts providing childhood methylation data in the following order: Upstate KIDS, HELIX, MMNP, PMMST. More details about each cohort are provided in supplementary materials with the publication.pval_FDR and HetPVAL_FDR are FDR p-values corrected for multiple testing for the association and the heterogeneity of the association between the cohorts contributing data in the meta-analysis, respectively.Citation: "Maternal age is related to offspring DNA methylation: A meta‐analysis of results from the PACE consortium" Aging Cell 2024