Recent evidence suggests that lncRNAs play an integral regulatory role in numerous functions, including determination of cellular identity. We determined global expression (RNA-seq) and genome wide pr

NIAID Data Ecosystem30

PRAMEL7 and CUL2 decrease NuRD stability to establish ground-state pluripotency

干细胞多能性调控

染色质复合体降解

Pluripotency is established in E4.5 preimplantation epiblast. Embryonic stem cells (ESCs) represent the immortalization of pluripotency, however, their gene expression signature only partially resembl

NIAID Data Ecosystem20

PCGF6, a polycomb group protein, regulates mesodermal lineage differentiation in murine ES cells and functions in iPS reprogramming. Mus musculus

干细胞多能性调控

iPSC重编程

Polycomb group (PcG) proteins comprise a large group of evolutionary conserved factors with essential roles for embryonic development and adult stem cell function. PcG proteins constitute two main mul

NIAID Data Ecosystem140

STAT3-dependent long non-coding RNA Lncenc1 contributes to ES cells pluripotency

干细胞多能性调控

非编码RNA功能分析

The self-renewal of Embryonic Stem Cells (ESCs) relies on a complex interplay of pluripotency transcription factors and their targets. LIF-activated STAT3 is a key player in regulating stemness by a n

NIAID Data Ecosystem20

esBAF is an essential component of the core pluripotency transcriptional network

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