Paired CRISPR screens to map gene regulation in cis and trans (HiChIP)
收藏NIAID Data Ecosystem2026-05-02 收录
下载链接：
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE255700
下载链接
链接失效反馈官方服务：
资源简介：
In this study, we develop a scalable approach that pairs discovery of cis- and trans-acting elements to systematically decipher the gene regulatory network. We explore the regulation of the immune checkpoint PD-L1 under both basal and IFNγ-stimulated contexts. PD-L1 expression on tumor cells serves as a clinically-actionable diagnostic for immune checkpoint blockade therapy across multiple cancer types. H3K27ac HiChIP for untreated and IFNγ-treated BxPC-3 human pancreatic adenocarcinoma cells
创建时间：
2024-11-28
