Phenotypic resistance of Y181C or K103N combined with different mutation sites in HIV-1 CRF_BC pol region to NNRTIs using an in vitro phenotypic assay.

Note:aThe unit for the EC50 values of TMC-125 is nM, while that for the EC50 values of DLV, NVP and EFV is µM. Data were presented as the mean ± standard deviations of three separate determination.bFold change was determined by calculating the ratio of EC50s for mutations and WT viruses.Each sample was tested in triplicate, and each experiment was repeated twice. EC50 (mM, except nM for maraviroc) data are presented as means 6 standard deviations.