Distinct Functions and Transcriptional Signatures in Orally Induced Regulatory T Cell Populations
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE242919
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We compared scRNA expression analysis of 3 populations of regulatory CD4+ T cells induced in oral tolerance to factor VIII in a mouse model of hemophilia: FoxP3+LAP-, FoxP3+LAP+, FoxP3-LAP+ Hemophilia A mice were orally gavaged with transplastomic lettuce expressing recombinant factor VIII. Animals then received intravenous injections of factor VIII. We performed scRNA analysis of FoxP3-LAP+ and FoxP3+ cells from spleen. FoxP3+ cells were further separated into FoxP3+LAP-, and FoxP3+LAP+ populations
创建时间：
2023-12-05
