Common lymphoid progenitor derivation of plasmacytoid dendritic cells is mediated by Bcl11a

Plasmacytoid dendritic cells (pDC) specialize in type I interferon production to coordinate innate and adaptive immunity. We identify two pDC subsets in vivo, evaluate their genome-wide expression, and demonstrate a developmental requirement for Bcl11a to provide insight into this enigmatic cell type. ChIP sequenicng was performed for a transcription factor of BCL11A in the Nalm6 B cell line and the Raji B cell line. Input was sequenced and used as a control.