Copy Number Variations identified in 225 Diffuse Large B-Cell Lymphoma tumors

Copy Number Variations (CNVs) were identified performing Comparative Genomic Hybridization (CGH) on 225 patients after whole-genome amplification, using Agilent SurePrint G3 4x180K microarrays. CNVs were further integrated with gene expression (Affymetrix U133+2 arrays) and mutations (targeted DNA resequencing). Complete description of the methods, array quality checks and called segments are available as supplemental material in the corresponding publication. 225 DNA samples extracted from frozen Diffuse Large B-Cell Lymphoma (DLBCL) tumors were hybridized against a commercial DNA pool. 6 arrays were discarded before analysis due to incomplete patient or expression data to correlate with. 29 more arrays were discarded after analysis due to an unrecoverable amplification bias (see the correspong publication for details), resulting in 190 exploitable arrays.