Heavy Menstrual Bleeding in Adolescents with Low VWF. Heavy Menstrual Bleeding in Adolescents with Low VWF

A multicenter observational cohort study to delineate the phenotype and genotype of adolescent females with low VWF–associated HMB was undertaken from February 2017 to June 2019. Tertiary care centers in North America, with expertise in hemostasis, which provided care for adolescents with HMB, and were members of the Foundation for Women and Girls with Blood Disorders, participated in the study. Institutional Review Board approval was obtained by all participating centers, and parental and/or patient consent/assent was obtained from all patients prior to study participation. Ten centers participated in this multicenter study. One hundred and thirteen adolescent females with a diagnosis of HMB and low VWF, who met the study inclusion and exclusion criteria, were enrolled. One patient was withdrawn because of the subsequent detection of type 1 VWD and factor XI deficiency. Of 126 the 113 patients enrolled, 86 had sufficient blood samples collected for WES, who formed the study population for this analysis.