A two-fold interpenetrating coordination polymer: protective effect in the acute glomerulonephritis treatment by reducing <i>tlr4</i> and <i>nf-κb</i> gene expression
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By using a mixed-ligand approach, a new Co(II)-based coordination polymer (CP) with the chemical formula of {[Co<sub>2</sub>(BIP)<sub>2</sub>(L)]·2H<sub>2</sub>O}<i><sub>n</sub></i> (<b>1</b>) (H<sub>4</sub>L = 5,5′-(triazole-2,5-diyl)diisophthalic acid, BIP = 4,4′-bis(imidazol-1-yl)phenyl) has been synthesized under hydrothermal conditions and characterized by single-crystal X-ray diffraction, IR spectroscopic, elemental and thermogravimetric analyses. To explore the activity of complex <b>1</b> on the treatment of acute glomerulonephritis (AGN), the mice model was constructed first. Then, the mice were given complex <b>1</b> for treatment and the level of 24-h urine protein contents was evaluated. Next, the RT-PCR was performed to detect the relative expression of important inflammatory factors for revealing the related mechanism.
