Structural characterization of pseudokinase-containing receptors.

Pseudokinases are inactive kinases that play crucial roles in human biology and various human diseases, such as cancers. However, our lack of understanding of their mechanisms of action limits our current ability to target them in the clinic. I aim to decipher the molecular mechanisms of pseudokinase-containing receptors by cryo-electron microscopy. Their structures will inform us how these receptors function and how their dysregulation leads to human diseases. Additionally, these studies will teach us how to target their pseudokinase domain to modulate the activity of the receptors, which may lead to new therapeutic avenues.