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Mechanistic dissection of dominant AIRE mutations in mouse models reveals evidence for AIRE auto-regulation

NIAID Data Ecosystem2026-03-13 收录

AIRE基因自身调控

自身免疫疾病机制

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE151013 数据链接链接失效反馈

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This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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创建时间：

2021-11-29

自身免疫疾病机制

细胞表型鉴定

Pathogenic T helper cells (Th cells) that respond to self-antigen cannot be easily distinguished from beneficial Th cells. These cells can generate systemic autoimmune disease in response to widely-ex

NIAID Data Ecosystem90

H3K27me3 ChIP-seq of naïve CD4 T cells. H3K27me3 ChIP-seq of naïve CD4 T cells

细胞表观遗传学

自身免疫疾病机制

Differentiation and activation of T cells require the activity of numerous histone lysine methyltransferases (HMT) that control the transcriptional T cell output. One of the most potent regulators of

NIAID Data Ecosystem60

Supporting data for "The role of AIM2 inflammasome in Systemic Lupus Erythematosus"

自身免疫疾病机制

炎症小体功能

Systemic Lupus Erythematosus is a chronic autoimmune condition in which the body mistakenly attacks itself. It’s aetiopathogenesis is highly complex. Increasing evidence suggests that the innate immun

DataCite Commons2021-09-15 更新50

Interleukin 6 Accelerates Mortality by Promoting the Progression of the Systemic Lupus Erythematosus-Like Disease of BXSB.Yaa Mice

自身免疫疾病机制

小鼠疾病模型

IL6 is a multifunctional cytokine that drives terminal B cell differentiation and secretion of immunoglobulins. IL6 also cooperates with IL21 to promote differentiation of CD4+ T follicular helper cel

Figshare2016-04-08 更新60

Genetically-driven target tissue over-expression of CD40: A novel mechanism in autoimmune disease

自身免疫疾病机制

免疫病理学

The CD40 gene, an important immune regulatory gene, is also expressed and functional on non-myeloid derived cells, many of which are targets for tissue specific autoimmune diseases, including d thyroi

NIAID Data Ecosystem50

Mechanistic dissection of dominant AIRE mutations in mouse models reveals evidence for AIRE auto-regulation

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