Additional file 1 of Metabolomic biomarkers of habitual B vitamin intakes unveil novel differentially methylated positions in the human epigenome

Additional file 1: Table S1. Cohort characteristics for the B vitamin metabolomic biomarker discovery. Table S2. Blood metabolites associated with the dietary intake of folate (B9) and vitamins B6 and B12 (metabolome-wide Bonferroni-adj. p < 0.05). Table S3. B vitamin metabolomic biomarker associations adjusted for diet quality (AHEI-2010) and total energy intake (metabolome-wide Bonferroni-adj. p < 0.05). Table S4. B vitamin metabolomic biomarker associations with other nutrient intakes (metabolome-wide Bonferroni-adj. p < 0.05). Table S5. Summary of nutrients associated with the B vitamin metabolomic biomarkers identified (metabolome-wide Bonferroni-adj. p < 0.05). Table S6. B vitamin metabolomic biomarker associations with circulating blood levels of folate (B9), vitamin B12, hcy and hcy-s. Table S7. Metabolite associations with circulating blood levels of folate (B9), vitamin B12, hcy and hcy-s (metabolome-wide Bonferroni-adj. p < 0.05). Table S8. Cohort characteristics for the B vitamin metabolomic biomarker epigenome-wide meta-analysis. Table S9. Annotation of the epigenome-wide association meta-analysis of folate (B9) and vitamins B6 and B12 biomarker metabolites (epigenome-wide Bonferroni-adj. p < 0.05). Table S10. Epigenome-wide association of folate (B9) and vitamins B6 and B12 biomarker metabolites in the KORA F4 cohort (epigenome-wide Bonferroni-adj. p < 0.05). Table S11. Epigenome-wide association of folate (B9) and vitamins B6 and B12 biomarker metabolites in the TwinsUK cohort (epigenome-wide FDR = 10%). Table S12. Cohort characteristics for the B vitamin intake epigenome-wide meta-analysis. Table S13. DMP results in DMP results in the epigenome-wide association meta-analysis of folate (B9) and vitamin B6 dietary intakes. Table S14. Cis expression quantitative trait methylation signals from the BIOS consortium for the DMP identified in this study. Table S15. Gene expression results for the genes annotated in the biomarker metabolite EWAS meta-analysis.