Copper-Catalyzed Activation of α‑Amino Peroxy and Hydroxy Intermediates to Iminium Ion Precursor: An Access to C4-Substituted 3,4-Dihydroquinazolines via Oxidative Cross Coupling Strategy

A simple
and straightforward approach to access C4-substituted-3,4-dihydroquinazolines
has been achieved, where copper-catalyzed activation of α-amino
peroxide and hydroxide intermediates to iminium ion precursors has
been realized as an important step. Reactions of these intermediates
with alkynes, indoles, pyrrole, and silylenol ether afforded the structurally
diverse C4-substituted-3,4-dihydroquinazoline derivatives in good
yields.