Management recommendations for clinically significant CNVs and recommendation according to the level of evidence.

Abbreviations: MCA = Multiple Congenital Anomalies; DD = Developmental Delay; ASD = Autism Spectrum Disorders; Dys = Dysmorphism; UCS = Uncertain Clinical Significance.Abbreviations: S = Surveillance; R = specialist Referral/assessment; D = Diagnostic testing; P = medical/surgical Procedure; M = Medication administration; L = Lifestyle recommendation; O = Other interventions.* = pathogenic CNVs, ∧ = likely pathogenic CNVs.N = not tested; Mat = maternal inheritance; Pat = paternal inheritance.Management recommendations for clinically significant CNVs and recommendation according to the level of evidence.