Steering sequences which minimize the probability of evolution to the highest peak of the landscape.

For each of the 15 antibiotic landscapes we have derived the (ordered) sets of one, two and three steering drugs which minimize the probability of evolution to the global fitness peak of that landscape. In the case that an ordered set of steering drugs reduced the probability to 0 we have not considered ordered sets of greater length (marked as—in the table).* As the landscape for SAM is single–peaked there can be no combination of steering drugs which reduce the probability of finding the global optimum. In all experiments the initial population distribution is taken as μ = [1/2N,…,1/2N] and r = 0.Steering sequences which minimize the probability of evolution to the highest peak of the landscape.