Parameters of our two-scale migration model.

References that support the parameters are given where available. The entry rates into LNs and spleen are not experimental estimates but are adopted from earlier modeling work [17]. However, these values accurately predict the T cell distribution over the organs at steady state, the blood residence time and the blood-to-lymph transit time (Table 2). The geometric parameters (T cell zone radius in LN and spleen, aperture radius in spleen) were set to values that are both anatomically reasonable and give realistic mean dwell times in LNs and spleen. The parameters shown in this table were used for all simulation results reported in this paper unless otherwise indicated. (*) The axillary, brachial and inguinal LNs are represented by 2 spheres each, while the mesenteric LN is represented by 4 spheres. Thus, in total, we have 39 spheres.