Association of birth weight with corneal power in early adolescence: Results from the National Health and Nutrition Examination Survey (NHANES) 1999–2008

PurposeTo analyze the effect of birth weight on ocular morphology, refraction and visual function in early adolescents aged 12–15 years.Material and methodsWe conducted a secondary data analysis using the public use files from the National Health and Nutrition Examination Survey of the period from 1999 to 2008. Study participants aged 12 to 15 years were included with data on birth weight and ophthalmic parameters including presenting distance visual acuity, objective refraction and keratometry. Visual acuity, sphere, astigmatism in power vectors J0 and J45, corneal power and corneal astigmatism were evaluated for an association with birth weight. Linear and logistic regression with adjustment for age, sex, ethnicity, survey cycle and birth weight as independent variable were calculated.ResultsLinear regression analysis revealed an association between corneal power and birth weight (per 100g: beta = -0.04, p0-vector and J45-vector of astigmatism, corneal J0- or corneal J45-vector with birth weight.ConclusionOur data demonstrate that low BW is linked to alterations in keratometric power even in early adolescents aged 12–15 years whereas visual acuity and refractive error showed no association.