p140Cap interactome in breast cancer cells

Even though neuronal and cancer cells have quite different purposes in the body, there is growing evidence that metastatic cancer cells implement signaling mechanisms found in homeostasis of synaptic growth/plasticity. Recent studies have highlight some remarkable similarities in both form and function of these two unique cell type. The p140Cap adaptor protein is an example of a mo-lecular hub that controls cancer cell migration and invasion through regulating protein complexes at cellular adhesions. Moreover, p140Cap in neurons is likely very important for normal brain function-ing, as it works as scaffold in postsynaptic signal transmission complexes and regulates F-actin re-modelling, which results in neuron dendritic spines synaptic plasticity It recruits and regulates signaling molecules both in breast cancer cells and in healthy neuronal synapses.