Chronic Colitis Impairs Cardiac Function by Suppressing Brain-Derived Neurotrophic Factor in the Adult Heart

Inflammatory bowel disease (IBD) represents a spectrum of chronic inflammatory mediated conditions with known extraintestinal complications. The interplay between patients with heart failure (HF) and IBD has previously been noted, but the mechanisms driving these changes have not been well elucidated. We elucidated mechanisms in which chronic colitis can impair cardiac function via alteration of miRNA expression.