Changes in Cell Cycle Dynamics and Related Mechanisms after png1 Gene Deletion

The bioinformatics data showed that the MAPK signaling pathway is the key pathway that causes abnormal cell cycle dynamics after the deletion of png1. Down-regulation of fkh2 and mob1 in png1deletion cells caused abnormalities of the spindle and cytokinetic actomyosin ring at room temperature, whereas under high-temperature stress, down-regulation of clr5 and rax2 was a key factor in making spin-dle and actin ring assembly blocked. This study provides some scientific basis for further exploring the function of Png1 protein in cell cycle dynamics and related mechanisms.