Mechanisms of variable ventilation in experimental lung injury. Rattus norvegicus

In the present study we seek to identify changes in lung gene expression under mechanical ventilation in uninjured as well as acutely and chronically injured lungs. A standard volume-controlled lung-protective ventilatory protocol is compared to a concept of mechanical ventilation using variable tidal volumes. Overall design: Comparison of mRNA profiles in whole-lung samples after mechanical ventilation with constant or variable tidal volumes