Mus musculus Transcriptome or Gene expression

Bone is a dynamic tissue that is constantly remodeled throughout adult life. Next to their roles as energy sources or posttranslational modifications, shor-chain fatty acids such as acetate activate the G protein-coupled receptors Gpr41 and Gpr43. However, the relevance of this signaling axis for bone metabolism is unclear. To define the potential intracellular signaling pathway, which might be regulated by acetate-dependent activation of Gpr41/43, we performed RNAseq analysis of wild type and Gpr41/43-deficient osteoblasts treated without or with acetate. This project contains 16 samples (4 wild type osteoblasts untreated, 4 wild type osteoblasts treated with acetate, 4 GPR41/43 ko osteoblasts untreated, 4 GPR41/43 ko osteoblasts treated with aceteat) of RNA-seq data.