Supplementary Material for: Osimertinib in the Treatment of EGFR Mutation-Positive Advanced Non-Small Cell Lung Cancer: A Meta-Analysis

<b><i>Background:</i></b> Non-small cell lung cancer (NSCLC) accounts for about 85% of generally reported lung cancer patients. <b><i>Objectives:</i></b> This is a systematic review of the clinical efficacy and safety of osimertinib in treating epidermal growth factor receptor (EGFR) mutation-positive advanced NSCLC. <b><i>Methods:</i></b> A network search was completed for clinical research literature (from inception of each database to May 30, 2020) on osimertinib for EGFR mutation-positive advanced NSCLC. Strict inclusion and exclusion criteria were formulated to screen the literature. After data extraction, RevMan 5.3 software was utilized for quality evaluation and meta-analysis. The primary endpoints were objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS), overall survival (OS), and adverse events of grades 3 and 4. <b><i>Results:</i></b> Finally, 6 eligible articles and a total of 1,848 patients containing 1,123 in experimental groups and 725 in control groups were included. Meta-analysis indicated that ORR (odds ratio [OR] = 3.40, 95% CI 1.64∼7.01, <i>p</i> = 0.0009), DCR (OR = 4.36, 95% CI 3.09∼6.15, <i>p</i> &lt; 0.00001), PFS (HR = 0.36, 95% CI 0.27∼0.47, <i>p</i> &lt; 0.00001), and OS (OR = 0.58, 95% CI 0.46∼0.72, <i>p</i> &lt; 0.00001) of the experimental group were prominently better than the control group. Adverse events of grades 3 and 4 mainly incorporated decreased nausea, rash, stomatitis, and vomiting, which were dramatically relieved compared with the control group. <b><i>Conclusion:</i></b> Osimertinib is currently an appreciably effective and well-tolerated therapeutic avenue for EGFR mutation-positive advanced NSCLC.