In both human and mouse, the NLRP6 sensor is translationally silenced outside of intestinal tissue. We find that alternative transcriptional promoters mediate this silencing in the mouse; a proximal p
Crystal structure of the N-terminal domain of Drosophila Toll receptor Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-g
BackgroundClostridioides difficile is the leading cause of nosocomial infectious diarrhea. Toll-like receptors (TLRs) are the major components of innate immunity that sense pathogens. The relationship
Crystal structure of TLR13-ssRNA13 complex Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DNA (5'-R(P*AP
