Crystal Structure of Human DPP4 Bound to TAK-294
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Crystal Structure of Human DPP4 Bound to TAK-294 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{[3-(aminomethyl)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-6-yl]oxy}acetamide, ... Authors: Yano, J.K, Aertgeerts, K. Deposit date: 2010-09-01 Release date: 2011-10-19 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.72 Å) Cite: Identification of 3-aminomethyl-1,2-dihydro-4-phenyl-1-isoquinolones: a new class of potent, selective, and orally active non-peptide dipeptidyl peptidase IV inhibitors that form a unique interaction with Lys554. Bioorg.Med.Chem., 19, 2011
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2010-09-01
