Lysosomal protein transmembrane 5 driving senescence in tubular epithelial cells accelerates chronic kidney disease progression.

Cellular senescence is associated with the progression of chronic kidney disease (CKD), and accelerated tubular cell senescence promotes the pathogenesis of renal fibrosis. We established three animal models related to Chronic Kidney Disease, including aristolochic acid nephropathy (AAN), bilateral ischemia/reperfusion injury (BIRI) and unilateral ureter obstruction (UUO). By RNA sequencing analysis in AAN, BIRI and UUO mice, we observed significant changes of senescence and fibrosis related genes. Overall design: The gene expression of 4 samples from the AAN mice was compared to 4 sham samples by RNA sequencing. The gene expression of 3 samples from the BIRI mice was compared to 3 sham samples by RNA sequencing. The gene expression of 4 samples from the UUO mice was compared to 4 sham samples by RNA sequencing.