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Crystal structure of NLRP3 in complex with inhibitor NP3-253

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Protein Data Bank Japan2024-12-25 更新2026-08-24 收录
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Crystal structure of NLRP3 in complex with inhibitor NP3-253 Descriptor: 2-[6-[[(3R)-1-ethylpiperidin-3-yl]amino]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol, ADENOSINE-5'-DIPHOSPHATE, NACHT, ... Authors: Srinivas, H. Deposit date: 2024-09-18 Release date: 2024-12-11 Last modified: 2024-12-25 Method: X-RAY DIFFRACTION (2.696 Å) Cite: Discovery of NP3-253, a Potent Brain Penetrant Inhibitor of the NLRP3 Inflammasome. J.Med.Chem., 67, 2024

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2024-09-18
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