Study Evaluating Oral MOA-728 for the Treatment of Opioid-Induced Bowel Dysfunction (OIBD) in Subjects With Chronic Non-Malignant Pain

NIAID Data Ecosystem2026-03-06 收录

阿片类药物肠功能障碍

慢性疼痛药物临床试验

数据链接：

https://www.omicsdi.org/dataset/ecrin-mdr-crc/2031936 数据链接链接失效反馈

官方服务：

资源简介：

The primary purpose of the protocol is to evaluate the safety, efficacy, and tolerability of MOA-728 in subjects with Opioid-Induced Bowel Dysfunction (OIBD) with associated chronic non-malignant pain.

创建时间：

2006-08-15

Chronic opioid use modulates human enteric microbiota and intestinal barrier integrity

肠道微生物组与药物相互作用

阿片类药物肠功能障碍

Over the past three decades the United States has experienced a devastating opioid epidemic. One of the many debilitating side effects of chronic opioid use is opioid-induced bowel dysfunction. We inv

NIAID Data Ecosystem70

A Randomized, Double-Blind, Placebo-Controlled, Multicenter Phase IIb Study to Evaluate the Efficacy and Safety of Multiple Alvimopan Dosage Regimens for the Treatment of Opioid-Induced Bowel Dysfunction in Cancer Pain Subjects.

癌症疼痛管理

阿片类药物肠功能障碍

Primary objectives: To identify at least one alvimopan treatment regimen that improves spontaneous complete bowel movement (SCBM) frequency compared to placebo while maintaining an acceptable tolerabi

NIAID Data Ecosystem30

A Randomized, Double-Blind, Placebo-Controlled, Multicenter Phase 3 Study to Evaluate the Long-Term Safety of Alvimopan 0.5mg Twice Daily for 12 Months for the Treatment of Opioid-Induced Bowel Dysfunction in Adults taking Opioid Therapy for Persistent Non-Cancer Pain

阿片类药物肠功能障碍

药物安全性评价

Primary objectives: To compare alvimopan with placebo for long-term safety and tolerability Primary endpoints: Incidence of reported clinical adverse events, including serious and non-serious adverse

NIAID Data Ecosystem20

阿片类药物肠功能障碍

药物疗效评估

Primary objectives: To identify at least one orally-dosed alvimopan treatment regimen that improves spontaneous bowel movement (SBM) frequency compared to placebo while maintaining an acceptable toler

NIAID Data Ecosystem40

Available IPD datapackage for study 'A Phase 3, Open-Label Period Followed by a Randomized, Double-blind, Placebo-controlled Study of the Analgesic Efficacy of Extended-release Hydrocodone/Acetaminophen (Vicodin CR) Compared to Placebo in Subjects With Chronic Low Back Pain'

慢性疼痛药物临床试验

镇痛效果评估

Vivli is an independent, non-profit organization that has developed a global data-sharing and analytics platform to serve all elements of the international research community. Our mission is to promot

DataCite Commons2024-12-02 更新20

Study Evaluating Oral MOA-728 for the Treatment of Opioid-Induced Bowel Dysfunction (OIBD) in Subjects With Chronic Non-Malignant Pain

资源简介：

相关数据集