Crystal structure of pVHL:ElonginC:ElonginB complex bound to PROTAC JW48
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Crystal structure of pVHL:ElonginC:ElonginB complex bound to PROTAC JW48 Descriptor: (2~{S},4~{R})-1-[(2~{S})-2-[3-[2-[2-[2-(acetamidomethyl)-4-(6,7-dihydro-5~{H}-pyrrolo[1,2-a]imidazol-2-yl)phenoxy]ethoxy]ethoxy]propanoylamino]-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... Authors: Kraemer, A, Weckesser, J, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2022-12-20 Release date: 2022-12-28 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization. Cell Chem Biol, 30, 2023
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2022-12-20
