Additional file 6: Table S5. of The dynamics of smoking-related disturbed methylation: a two time-point study of methylation change in smokers, non-smokers and former smokers

Gene overrepresentation analysis results based on the WebGestalt platform ( webgestalt.org ). For each TSQL category we extracted the CpG sites that showed nominal significance (p < 0.05) for that category or any later category and ran the WebGestalt overrepresentation enrichment analysis (based on the GLAD4U disease functional database, the default parameters (5–2000 genes per category, Benjamini-Hochberg multiple-testing correction) and the reference set “illumina_human_methylation_450”). Displayed are the top 10 diseases based on p-value. C: the number of reference genes in the category. O: the number of genes in the used gene list and also in the category. E: the expected number in the category. R: ratio of enrichment. PValue: P-value from the hypergeometric distribution. FDR: FDR from the Benjamini-Hochberg adjustment (XLS 44 kb)