S1 Dataset: Sequential in silico filtering of GIPR missense variants

This workbook is the S1 Dataset accompanying an in silico study of missense variants in the human glucose-dependent insulinotropic polypeptide receptor (GIPR). It contains the complete per-stage variant lists from the sequential filtering pipeline: beginning with 893 missense single-nucleotide variants from dbSNP, variants were filtered through PolyPhen-2, gnomAD allele frequency, SIFT 4G, PROVEAN, AlphaMissense, MetaRNN, REVEL, and mCSM-membrane (pathogenicity classification followed by stability ΔΔG), producing a final set of 14 prioritized variants. Each worksheet lists the variants retained at that step with the relevant prediction scores. Coordinates are reported on the GRCh38 assembly, and the counts correspond to Table 1 and Fig 1 of the associated manuscript.