File S1 - Are C-Reactive Protein Associated Genetic Variants Associated with Serum Levels and Retinal Markers of Microvascular Pathology in Asian Populations from Singapore?

Combined supporting information file containing supporting tables and figure. File includes: Table S1, Sample QC threshold of GWAS datasets used in study; Table S2, SNP QC thresholds utilised for GWAS datasets used in study; Table S3, Details of 35 index CRP SNPs identified from previous GWAS; Table S4, Genome-wide hits for serum CRP association after meta-analysis of SINDI, SP2 and SiMES; Table S5, Full association results of known CRP index variants in SP2, SiMES and SINDI datasets and after meta-analysis; Figure S1, Central retinal arteriolar equivalent and the central retinal venular equivalent from retinal fundus photograph using the Interactive Vessel Analysis; Figure S2, Forest plots comparing effect estimates from individual datasets and after fixed effect meta-analysis of all 14 SNPs that were observed to be significant for serum CRP association in the Singapore datasets; Figure S3, Inter-population pair-wise varLD comparison of Han Chinese population (CHB) and European population (CEU) from HapMap and Singaporean Chinese (CHS), Singaporean Malays (MAS) and Singaporean Indian populations from SGVP at the GPRC6A and PTPN2 loci; Figure S4, QQ-plot for CRP association p-values of fixed-effect meta-analysis of all 3 Singaporean datasets (SP2, SiMES and SINDI) (N = 6,692) after removal of SNPs at 22 known CRP gene loci. (DOC)