A dual function for the chromatin organizer Special A-T rich Binding Protein 1 in mature B-lineage cells. undefined

NIAID Data Ecosystem2026-03-13 收录

染色质组织蛋白功能

B细胞发育

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJEB52320 数据链接链接失效反馈

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资源简介：

A dual function for the chromatin organizer Special A-T rich Binding Protein 1 in mature B-lineage cells

创建时间：

2022-09-01

Phospholipase Cγ pathway-dependent mTOR signaling controls IL-7-mediated early B cell development. Mus musculus

B细胞发育

信号转导分析

We examined the global gene expression profile of PLCγ1/PLCγ2 double-deficient CLPsand B cell progenitors by RNA-seq analysis. Overall design: CLPs (Lin-IL-7R+) and B cell progenitors (B220+IgM-IL-7R+

NIAID Data Ecosystem100

Polypyrimidine tract binding proteins are essential for B cell development. Polypyrimidine tract binding proteins are essential for B cell development

B细胞发育

转录调控

During B cell development, recombination of immunoglobulin loci is tightly coordinated with the cell cycle to avoid unwanted rearrangements of other genomic locations. Several factors have been identi

NIAID Data Ecosystem50

Induction of extracellular adenosine salvage and metabolic quiescence regulate the transitional to follicular B cell checkpoint in humans.

免疫代谢

B细胞发育

Transcriptional profiling of transitional and follicular B cells showed that metabolic quiescence was acquired at the follicular B cell stage in both humans and mice, characterized by an orchestrated

NIAID Data Ecosystem10

The spliceosome component Usp39 controls B cell development by regulating immunoglobulin gene rearrangement. The spliceosome component Usp39 controls B cell development by regulating immunoglobulin gene rearrangement

B细胞发育

剪接体功能

The spliceosome is a large ribonucleoprotein complex responsible for pre-mRNA splicing and genome stability maintenance. Disruption of the spliceosome activity may lead to developmental disorders and

NIAID Data Ecosystem60

BCR and TLR-induced IRF1 promotes T cell independent B cell responses by supporting Notch2 dependent Marginal Zone B cell development

B细胞发育

T细胞非依赖性抗体应答

The prototypic interferon (IFN)-inducible transcription factor, IRF1, not only controls expression of IFN genes but also regulates T cell and macrophage fate specification and function. We show that I

NIAID Data Ecosystem40

A dual function for the chromatin organizer Special A-T rich Binding Protein 1 in mature B-lineage cells. undefined

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