New Aspects of Catalytic Intramolecular C−H Amination: Unexpected Formation of a Seven-Membered Ring in Nitrogen-Containing Systems

The first example of the formation of a seven-membered ring by way of intramolecular-catalyzed amination of saturated C−H bonds is reported
(Du Bois reaction). The influence of various structural parameters was studied, and it was shown that the unexpected regioselectivity observed
in nitrogen-containing systems could be rationalized by conformational factors. These results open the way to innovative strategies for the
general synthesis of polyfunctionalized piperidines.