Crystal structure of the first bromodomain (BD1) of human BRDT bound to GXH-IV-075
收藏Protein Data Bank Japan2023-10-18 更新2026-04-19 收录
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Crystal structure of the first bromodomain (BD1) of human BRDT bound to GXH-IV-075 Descriptor: 4-[(4-{4-chloro-3-[(2-methylpropane-2-sulfonyl)amino]anilino}-5-methylpyrimidin-2-yl)amino]-2-fluoro-N-[1-(14-{3-[(2-{3-fluoro-4-[(piperidin-4-yl)carbamoyl]anilino}-5-methylpyrimidin-4-yl)amino]-5-[(2-methylpropane-2-sulfonyl)amino]phenyl}-14-oxo-4,7,10-trioxa-13-azatetradecanan-1-oyl)piperidin-4-yl]benzamide, Bromodomain testis-specific protein, SODIUM ION Authors: Chan, A, Schonbrunn, E. Deposit date: 2022-05-24 Release date: 2022-08-03 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.96 Å) Cite: Bivalent BET Bromodomain Inhibitors Confer Increased Potency and Selectivity for BRDT via Protein Conformational Plasticity. J.Med.Chem., 65, 2022
创建时间：
2022-05-24
