COMMUNITY study

The COMMUNITY study is a longitudinal cohort study including 2149 healthcare workers and 118 COVID-19 patients. <br>Dataset includes:1. Serological data at baseline April-May 2020 and at four-month follow-up.<br>2. Self-reported symptoms compatible with COVID-19 since 1 January 2020, occupation, work location and exposure to patients infected with COVID-19 prior to blood sampling (healthcare workers). <br>3. Clinical data including co-morbidities, laboratory data, disease severity, on-going medications, demography (COVID-19 patients).<br><br><b>Abstract</b>The COMMUNITY study is a large longitudinal cohort study including 2149 healthcare workers and 118 hospitalized COVID-19 patients. The aim is to obtain a deeper understanding of the generation and dynamics of SARS-CoV-2 immune memory (humoral and cellular). We also aim to map and investigate virus and immune-mediated persistent symptomatology, so called long-COVID, and susceptibility/resistance to SARS-CoV-2. Study inclusion was initiated April 2020, and serial blood samples are obtained every four months. 19% of healthcare workers had been infected with COVID-19 at study inclusion, and the vast majority reported no or mild symptoms, thus representing the portion of society generating the most transmission. The cohort, including the extensive database, allows for a comprehensive mapping of long-COVID which can be used to help target early interventions aimed at capturing, preventing and treating this condition.<br><b>Publications</b><b> </b><b>SARS-CoV-2 exposure, symptoms and seroprevalence in healthcare workers in Sweden. </b>Nat Commun 2020. (2020-10-08) https://doi.org/10.1038/s41467-020-18848-0<br><b>SARS-CoV-2 induces a durable and antigen specific humoral immunity after asymptomatic to mild COVID-19 infection.</b> (2021-01-04) DOI: https://doi.org/10.1101/2021.01.03.21249162<br><b>Circulating Markers of Neutrophil Extracellular Traps Are of Prognostic Value in Patients With COVID-19. </b>Arterioscler Thromb Vasc Biol. 2020. (2020-12-03) 10.1161/ATVBAHA.120.315267<br><b>Patients With COVID-19 Have Elevated Levels of Circulating Extracellular Vesicle Tissue Factor Activity That Is Associated With Severity and Mortality. </b>Arterioscler Thromb Vasc Biol. 2020. (2020-12-03) 10.1161/ATVBAHA.120.315547 <b>Elevated factor V activity and antigen levels in patients with COVID-19 are related to disease severity and 30-day mortality. </b>Am J Hematol 2020. (2021-01-04) https://doi.org/10.1002/ajh.26085<br> <b>Development and external validation of a logistic regression derived formula based on repeated routine hematological measurements predicting survival of hospitalized Covid-19 patients</b>. (2020-12-22)<b> </b>https://doi.org/10.1101/2020.12.20.20248563<br>