Additional file 5 of Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity

Additional file 5: Table S3. List of proteins identified in label free MS analysis of amyloid fibrils isolated from human AD cortices. Proteins with significantly higher abundance in purified fibrils obtained from human brain cortices, with amyloid (A) score 2 and 3 (N= 13 and 23 patients respectively), compared to respective cortex homogenate as input (N = 4). NSAF values for purified fibrils and cortex homogenates for individual proteins were used. Separate sheets are provided for A2 and A3 brain amyloid fibrils data sets, and each row has individual p values using Student’s t test, followed by adjusted p values with BH correction. Number of significantly high abundance proteins in A2 and A3 fibril cores are 252 and 330, respectively. Experiment = specific data set, Uniprot accession = Uniprot identifier for each protein, ratio= log2 average NSAF values (purified fibrils/homogenate), t test p value = t test p value, Rank = rank ordered proteins based on p value (if p values are identical, higher ratio was listed first), description = protein description. Additional remarks indicate if results (increased abundance in purified fibrils) are statistically significant or not.