Maternal High-Fat Diet and Offspring Gut Microbiota

Alterations in the gut microbiome have been implicated in obesity. Maternal high-fat diet (HF) contributes to shaping the composition of the gut microbiome in offspring, yet the sex-specific responses have not been fully elucidated. Moreover, the effects on the gut microbial and functional profiles resulting from the interactions between maternal and postnatal dietary challenges in offspring remain unclear. This study investigated the effects of maternal HF diet on offspring gut microbiota structure and predicted functional profile in response to short-term postnatal HF diet exposure with a focus on sex-specific responses.