Hsa-miR-375/RASD1 signaling predicts local control in early breast cancer. Hsa-miR-375/RASD1 signaling predicts local control in early breast cancer

The current analysis was a two phase study. The first step of the pilot phase comprised an in-silico search for potential target molecules in five different databases. The second step was a screen for potential targets in 28 patients (14 with local relapse and 14 matched controls) by means of microarray technology. The combined results formed the basis for the validation phase in an independent set of 53 patients performed with droplet digital PCR (ddPCR). Overall design: 28 patients (14 with local relapse and 14 matched controls)