An Efficient and Straightforward Access to Sulfur Substituted [2.2]Paracyclophanes: Application to Stereoselective Sulfenate Salt Alkylation

A straightforward and high-yielding access to various [2.2]paracyclophanes possessing a sulfur-based functional group is reported, the key step being a SEAr reaction mediated by a sulfonium salt. The versatility of the methodology was exemplified by an original application in sulfenate salt chemistry, from which a remarkable chirality transfer was observed.