Integrated Interactions Database

Integrated Interactions Database (IID) 是一个蛋白质-蛋白质相互作用(PPI)数据库，提供多种生物体(包括人类、小鼠等)的蛋白质相互作用数据。用户可以通过基因符号、UniProt ID或Entrez Gene ID查询蛋白质相互作用，并可根据实验证据、发育阶段、疾病、亚细胞定位等多种条件进行筛选。该数据库还包含蛋白质相互作用的方向性、可成药性、突变效应和对接数据等高级功能。The Integrated Interactions Database (IID) is a protein-protein interaction (PPI) database that provides protein interaction data for multiple organisms including humans, mice and others. Users can query protein interactions via gene symbols, UniProt IDs or Entrez Gene IDs, and filter the results based on various criteria such as experimental evidence, developmental stages, diseases, subcellular localization and more. This database also offers advanced features including the directionality of protein interactions, druggability, mutation effects and docking data.

搜集汇总

背景与挑战

背景概述

Integrated Interactions Database (IID) 是一个涵盖人类、小鼠等18个物种的蛋白质-蛋白质相互作用数据库，支持通过基因符号、UniProt ID等多种标识进行查询，并允许根据实验证据、发育阶段、疾病、亚细胞定位等条件进行筛选。该数据库还提供相互作用的方向性、可成药性、突变效应等高级功能注释，整合了实验、预测和同源数据，总计包含超过1200万次相互作用。