Survival of RML-infected CD-1 mice treated with AAV2-PrP-shRNA and GSI/Qa was very similar to that of untreated control mice.
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4 µl of AAV2-PrP-shRNA was infused to the thalamus bilaterally at 50 dpi and the next day, AAV-infused mice were treated with 5 mg/kg/day of GSI and 40 mg/kg/day of Qa for 28 days. The average survival time was calculated based on the onset of prion disease. Mice were euthanized one day after they showed scrapie-sick symptoms.
创建时间：
2015-12-02
